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Solution is SIR (i.e

doi:10.1016/j.mayocp.2014.11.004

Properties of tobacco leaves in traditional medicine, while tobacco leaves have been used in traditional medicine for centuries, it is important to note that tobacco is a very addictive substance and if used excessively or in large quantities, it can have severe negative effects on the body

Nicotinell TTS 30 patches (52.5 mg of nicotine) delivering 21 mg per 24 hours to a smoker, Nicotinell TTs 20 patches (35 mg of nicotine) delivering 14 mg per 24 hours, and Nicotinell TTS 10 patches (17.5 mg of nicotine) delivering 7 mg per 24 hours

Reference Jackson, Diaz, Lopez and Leon2 This is important since in people with bipolar disorder smoking is associated with negative physical and mental health outcomes compared with non-smoking