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In 2008 the WHO stated that e-cigarettes are not a legitimate smoking cessation tool, and 37 countries currently ban the sale of e-cigarettes (GGTC, 2021)

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Given that PLWH are roughly twice as likely as the general population to smoke cigarettes [3,4,5] and have more trouble quitting [3, 4], and that nicotine (a primary constituent of tobacco smoke) is anti-inflammatory [6] and pro-cognitive [7], understanding the effects of being HIV+ and cigarette smoking on neuroinflammation and cognitive control in PLWH is crucial