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The RTP developed in this study was intended for use in a clinical trial (ISRTCN81286286) in Hamburg, Germany, the protocol of which is described elsewhere (Shepperd et al.2013b), among German smokers of 68 mg ISO yield cigarettes

So, when smokers use them, they still inhale these elements, posing health risks such as nicotine dependence, various types of cancer, and other serious illnesses