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Discussion Given the critical role of mitochondrial function in the pathophysiology of COPD and its reported association with nDNA methylation, we set out to explore the effect of cigarette smoke exposure on DNA methylation of the mitochondrial genome
We expect that the OHP would have provided feedback to the contractor about this work because at the time this progress report was due, this contractors agreement term had less than six months remaining
Figure 4 Figure 5 ENDS exposure induces lipid dysregulation and ferroptosis in mice We noticed that the level of cell death detected by TUNEL staining (either apoptosis or necrosis) does not fully match with lung tissue destruction by ENDS as shown in histological staining
