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Over this ten-year period, the number of variants offered in the main brand range shrank slightly so the total number of single pack products was only marginally higher in 2014 compared to 2004

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The present study, as part of the Global Burden of Diseases, Risk Factors, and Injuries Study (GBD) 2020, re-estimated the continuous doseresponse relationships (the mean risk functions and associated uncertainty estimates) between current smoking and 36 health outcomes (Supplementary Table 1) by identifying input studies using a systematic review approach and employing a meta-analytic method 28