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This puzzle has been engaging my attention for many years

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Since the 2010s, when cigarette commercials were completely banned, advertisements using such landscapes could not be created, and in some countries, cigarette packaging laws were implemented, so even Marlboro's existing logo could not be used.[6] 4

Edwards KD, Fernandez-Pozo N, Drake-Stowe K, Humphry M, Evans AD, Bombarely A, Mueller L (2017) A reference genome for Nicotiana tabacum enables map-based cloning of homeologous loci implicated in nitrogen utilization efficiency

Which one of these is a disease caused by smoking