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Moreover, cigarette and tobacco excise taxes are highly regressive and these proposed tax rate increases will fall most heavily on those who are least able to afford paying such high product tax rates
Nicotine, the principal component of TS and e-cig, can negatively affect tight junctional protein expression, compromising BBB integrity ( Moreover, the comparative effect of TS and e-cig extract showed that downregulation of ZO-1 protein from e-cig was not dissimilar to that from TS extract treatment (Kaisar et al., 2017)
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Thus, age and nicotine exposure may influence executive brain function 35
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