In addition, criticisms about the translation of these results into clinical practice have been raised, for instance because of differences in the physiology and breathing behaviors between humans and rodents as well as the use of non-physiological exposure methods such as whole body exposure instead of mouth breathing [7, 18]
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A 2021 study from Russia followed 517 people diagnosed with early-stage non-small cell lung cancer (NSCLC) who currently smoked
in middle school students, the reported use increased from 20 days in the last 30 days) of smokeless tobacco was most prevalent among high school students (42%) and middle school students (29.2%)