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This is often a reflection of the persons internal conflicts

Epithelialmesenchymal transition (EMT) is a unique biological process, that refers to epithelial cells losing their polarity and transforming into mobile mesenchymal cells, playing a crucial role in organ development, fibrosis, and cancer progression

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A 2012 study, however, tested the effects of reducing the actual nicotine content in cigarettes and had two main findings: 1) reducing nicotine content in cigarettes leads to a decline in nicotine in the blood and urine as well as a decrease in cigarette smoking and 2) there is a nicotine-reinforcement threshold beyond which smokers tend to relapse after 6-8 weeks