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Whenever I see sarcomatoid carcinoma and it doesnt pick up a MET mutation, I really make sure we are looking hard enough because of the enrichment seen in this specific subset of NSCLC. Clinicians may need to obtain another biopsy or get information from cell-free DNA in cases where there are certain features with high suspicion for targetable driver mutations

For example, one big study showed current e-cigarette users had about 2 the odds of reporting a history of depression compared with never-users

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But just because you can detect a statistically significant difference in one or two specific things in a lab doesnt mean it really matters in practice

This often contributes to a more positive vaping experience