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Duration of Use : Higher doses of a drug can lead to more pronounced physical dependence

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Nicotine gum is a helpful tool in smoking cessation, providing a controlled dose of nicotine, which can help reduce cravings and withdrawal symptoms

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The unexpected but interesting result was that procyclidine prevented the reduced locomotor activity induced by nicotine withdrawal, but this effect was not observed after inhibition of the cholinergic interneurons, said Kim