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This is particularly noteworthy given that nicotine replacement was used under expert guidance, with access to the full range of nicotine replacement products, and with 88.1% of participants using combination treatments, said investigator Peter Hajek, PhD, of Queen Mary University of London, and his coauthors in the New England Journal of Medicine

Withdrawal symptoms include cravings, restlessness, trouble sleeping, irritability, depressed mood, and weight gain

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Regulatory enforcement that constrains claims Compliance requirements around labeling, marketing language, and product presentation affect how herbal attributes are communicated

Nerve conduction and electromyography studies most frequently show a sensory-motor axonopathy and can document severity and progression