The two versions of the comparator product were identical except version 1 used cork tipping paper, whereas version 2 had white tipping paper, a purely visual difference
For example, a study of Canadian researchers shows that when comparing smoking joint vs cigarette, cannabis gives 20 times more ammonia than tobacco, and up to 5 times more prussic acid, nitrogen oxide, and various aromatic amines
After wisdom tooth removal, experts strongly advise avoiding smoking or vaping due to the significant risks it poses to healing
Laden et al
Hence, one might postulate that given the potentially large effect size of the aforementioned factors associated with both smoking status and IBD, that the magnitude of any direct mechanistic or toxic effect of smoking constituents on the intestinal milieu or treatment(s) might in fact be dwarfed by these cofactors, as represented in Fig