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In our cEDS cohort, headache/migraine and chronic fatigue were referred respectively by ~ 41% and ~ 36% of cEDS patients, especially by adults even though not statistically significant, whereas impaired memory and concentration and paresthesia were both more recurrent in adults (~ 40% vs ~ 10%)

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Also, exposure to THC during adolescence can impact structural, molecular, and functional alterations of brain circuits, especially in areas involving cognition and behavior

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[13] Progressive muscle relaxation involves tensing and subsequently relaxing each group of muscles progressively, from one end of the body to the other