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Nowadays, molecular analysis, especially for doubtful patients, should rely on next generation sequencing (NGS) technologies, including multigene panels containing at least all EDS-associated genes and/or panels comprising genes of the major HCTDs in differential diagnosis and/or a custom phenotype-focused whole exome analysis [1]

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It is also necessary to indicate the distances between the place of installation and the nearest retailers if the cigarette vending machines are located within public services in the area of commercial interest of the retailer, at a distance of more than 10 metres from the retailer itself

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