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As a percentage of the mortality among those who had never smoked regularly, the excess among current cigarette smokers was consistently higher in the second half than in the first, particularly in late middle age
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Consistent with the notion that structural alterations in these regions are a product of prolonged nicotine/tobacco exposure, group differences between smokers and nonsmokers within, for example, the insula were not detected among an adolescent/young adult participant sample with relatively lower exposure levels (0.9 0.7 pack-years on average) [85] but were observed among similarly aged individuals with relatively higher exposure levels (4.0 1.8 pack-years) [86]
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