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The problems facing the European machine-rolled business are not mild nor fleeting

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Since the dominant CYP2A6-generated metabolite of nicotine is cotinine, whose t 1/2 is ~16 h compared with ~2 h for nicotine, and whose plasma levels are considerably higher than those of nicotine (275 versus 15 ng/mL) [37], cotinine is used as an indicator of environmental exposure to tobacco smoke

These include leaf thickness, moisture content, vein structure, and overall appearance

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