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While individuals were anxious and nervous about the risks of smoking, the negative health effects of tobacco were not initially known,[2] and tobacco manufacturers attempted to alleviate such concerns by incorporating doctor images to assure the consumer that their respective brands were safe.[3] Tobacco manufacturers may have been well aware of the health risks associated with their products, yet without substantial evidence and research, these firms continued to profit from significant cigarette consumption throughout the 20 th century

Lung cancer risk drops to half that of a non-smoker by 10 years and almost equals a non-smoker within 15 years

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Animal models have demonstrated that nicotine can increase renal injury through various mechanisms, such as raising blood pressure, decreasing GFR, and increasing the effective renal plasma load 26