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Tobacco smoke exposure impairs brain insulin/IGF signaling: potential Co-factor role in neurodegeneration

PMID 22345227

In addition, it seems that the 7 subunit is a key component of the relevant receptors

Over the last two years, a new approach called genome wide association studies has allowed scientists to identify specific sites within the human genome associated with increased risk for lifestyle diseases such as diabetes, colon cancer and heart disease diseases associated with how you live your life