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Zhong, Clinical Characteristics of Coronavirus Disease 2019 in China, New England Journal of Medicine, 2020
Additionally, nitrosamines derived from betel quid and tobacco mediating oxidation of thiol group of antioxidants such as glutathione-S-transferase, superoxide dismutase (SOD), glutathione reductase, glutathione peroxidase (GPx), and catalase (CAT) were reported (Shiu and Chen, 2004) to induce changes in oral microbiome communities contributing to oral carcinogenesis (Lee et al., 2017
High-humidity environments present the opposite problem
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This would occur from 30 to 60 minutes of use, however this would be based on the brand, users tolerance and manufacturer
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