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The pattern holds everywhere one looks

In the 1970s, scientists at RJ Reynolds were trying to figure out why their competitors cigarette brand was outselling Winston cigarettes, so they reverse engineered the Marlboro, and discovered that, by adding ammonia to the tobacco, Phillip Morris was raising the alkalinity and creating free nicotine, which was rapidly absorbed getting to the brain faster than an intravenous injection

Look for papers that burn slowly and evenly

doi:10.1093/ntr/ntae011