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Nicotine vaping is substantially less harmful than smoking

Moreover, CS-induced COPD disrupted gut microbiota, reducing Akkermansia and Escherichia-Shigella , and activated the STAT3/NCOA4 pathway, promoting oxidative stress, inflammation, and ferritinophagy

A central mechanism across all nicotine products Experimental and clinical studies confirm that nicotine activates the sympathetic nervous system, increases heart rate and BP, induces oxidative stress, and reduces NO availability

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