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In the EU, 20 mg/mL is the legal maximum under the Tobacco Products Directive

Hays JT, Hurt RD, Rigotti NA, Niaura R, Gonzales D, Durcan MJ, Sachs DP, Wolter TD, Buist AS, Johnston JA, White JD

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In addition, the United States Surgeon General has concluded that there is no risk-free level of exposure to ETS and that exposure to ETS in adults has immediate adverse effects on the cardiovascular system and causes coronary heart disease and lung cancer (United States Surgeon General, 2006)