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(3) activating a range of antioxidant enzymes such as GST, GSH-Px, GR, SOD, and CAT as well as non-enzymatic antioxidants, generally through different transcription factors (TFs) including NF-kB-Nrf2 pathway

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It has already been shown that there is a relationship between telomere shortening and lifespan, hence these dogs will likely have shorter lives