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Tobacco, both product and plant, followed the major trade routes to major ports and markets, and then into the hinterlands

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Phototoxicity and environmental transformation of polycyclic aromatic hydrocarbons (PAHs)-light-induced reactive oxygen species, lipid peroxidation, and DNA damage

But a large majority of the tobacco was earmarked for cigars, meaning each plant needed to be carefully harvested by hand, out in the summer heat