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The part of the smoke formed during puffing is mechanistically and kinetically dependent on combustion/pyrolysis reactions, and therefore it takes longer for this smoke to be detected at the mouth end

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With the advent of new technologies in molecular analysis, such as gene expression profiling, networks, microRNAs, gene discovery, and pathway analysis, carcinogenesis is proving to be much more complex than being simply a clonal evolution of a cell that sustained two genetic hits by a carcinogen