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In addition, the same structural fragmentation also weakens compliance and expands opportunities for illicit cigarettes, as complex classifications and the presence of very low-priced legal products facilitate misclassification, tax evasion and illegal market entry, ultimately undermining public health goals, weakening national security safeguards and reducing government revenue (Ardana et al., 2025) Furthermore, the Multiple Streams Framework (MSF) [5] adds explanatory value by clarifying why simplification advances only when certain conditions align

"As a pulmonologist, I advise my patients against e-cigarettes

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Studies demonstrated that cigarette smoking or nicotine treatment, by upregulating Bcl-2, decreased the susceptibility of cancer cells to apoptosis or augmented the resistance of cancer cells to chemotherapies (Zangemeister-Wittke et al, 1998