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Given the possibility that some antidepressants are metabolized by CYP induced or inhibited by substances in tobacco, their identification can be a guide for drug initial choice in smoking patients, allowing a more accurate antidepressant selection and consequently improving the pharmacologic treatment of depression in smokers

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This could have been the case up until the early 1990's when a federal ban was passed by Congress officially banning inflight smoking (1)

[115] Two weeks later, [116] he returned to the studio to find that Harrison had covered his drum kit in flowers as a welcome-back gesture