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Policy should ease access to smoke-free nicotine products The transition underway in the US mirrors Swedens long-standing experience with less harmful smokeless alternatives, where widespread snus use has led to the lowest smoking rates and tobacco-related health issues in Europe

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Chemicals and standard reference materials Sigma-Aldrich (St Louis, MO) provided the HPLC-grade solvents, the authentic standard reference materials for nicotine, nornicotine, cotinine, myosmine, and for the surrogate standard (SS) chemical (quinoline) and the internal standard (IS) chemical (1,2,3-trichlorobenzene)

Carefully evaluate patients with fever to rule out severe neutropenia or infection