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Still, its natural setting remained the open landscape of the American West, a focus that became more pronounced over time

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Obesity further contributes to systemic low-grade inflammation, especially via visceral fat accumulation and metabolic dysfunction, leading to increased levels of IL-6, C-reactive protein, and tumor necrosis factor- (TNF-), which can trigger or worsen airway hyperresponsiveness 32

[156] [157] In May 2026, Hanks executive produced and narrated The History Channel documentary series World War II with Tom Hanks

These stains, in the presence of poor oral hygiene, can also result in a dark brown line along the gingival margins of the affected teeth