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These manufactured formulations are illegal in California and many other states, and studies have linked their use to heart problems

Carbon Monoxide Carbon monoxide is produced when the heme is catalyzed by the enzyme heme oxygenase-1 (HO-1) expressed in immune cells ( However, it is unclear why smoking, which also produces CO, has not been found to prolong allograft survival

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19 According to recent statistics, the prevalence increases with age, is higher in females than in males (56.8 versus 29.6 cases/ 1000 persons, respectively) and is higher in non-Hispanic blacks and whites compared to Hispanics (48.6, 47.3 and 28.8/ 1000 persons, respectively) (Figure 1)

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