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Abbreviations CHX: Cycloheximide COPD: Chronic obstructive pulmonary disease CSE: Cigarette smoke extract DAMP: Danger-associated molecular pattern IL: Interleukin LPS: Lipopolysaccharide NLR: NOD-like receptor NOD: Nucleotide-binding oligomerization PAMP: Pathogen-associated molecular pattern SDS-PAGE: Sodium dodecyl sulfatepolyacrylamide gel electrophoresis TCA: Trichloroacetic acid References Chaput C, Sander LE, Suttorp N, Opitz B

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Mortality Follow-up Details of the mortality follow-up protocol for each cohort are available in Section 1 in the Supplementary Appendix