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For example, ibuprofen should not be taken with: High doses of aspirin Prescription NSAIDs such as Toradol (ketorolac) and celebrex (celecoxib) Blood-thinning agents such as warfarin, rivaroxaban, or apixaban due to an increased risk of bleeding Please consult your pharmacist or doctor before taking ibuprofen if you are already taking other medications to avoid a potentially dangerous drug interaction

Marieh Honarmand, Alireza Nakhaee, and Mohammad Moradi, Comparison of Salivary Cotinine Concentrations in Male Smokers and Smokeless Tobacco Users, 2018