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In 2018, Mehan and colleagues explored solanesols neuroprotective effects against Huntingtons disease (HD), suggesting that solanesol may slow disease progression by improving mitochondrial dysfunction and reducing oxidative stress-induced neuronal damage ( In 2020, Alam from Mehans team investigated the therapeutic effects of solanesol alone at doses of 15 and 30 mg/kg and in combination with riluzole in a methylmercury-induced amyotrophic lateral sclerosis (ALS) rat model ( In 2024, research has found that in a zebrafish Parkinsons disease (PD) model induced by Tramadol, motor dysfunction and motor coordination in the zebrafish PD model were reversed after treatment with solanesol alone at doses of 25, 50, and 100 mg/kg, as well as in combination with standard drugs ( 4 Druggability Solanesol, a long-chain unsaturated fatty alcohol composed of nine isoprene units with nine non-conjugated double bonds, exhibits unique chemical properties that underpin its diverse bioactivities