increased heart rate smoking cigarettes affects the long before symptoms appear. Each cigarette delivers chemicals that enter the bloodstream within seconds, reaching the heart and blood vessels almost immediately. These substances damage the inner lining How Nicotine and Tobacco Affect

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Cigarette smoke extract (CSE) induces mtROS accumulation in pulmonary epithelial cells, promotes phosphorylation of Dynamin-Related Protein 1 (Drp1) at Serine 616(Ser616), stabilizes the mitophagy regulator PTEN-Induced Kinase 1(PINK1), and triggers mitophagy, leading to cell death and worsening COPD (Mizumura et al., 2014)