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Therefore, we aim to test a secondary hypothesis that baseline nicotine metabolite ratio (NMR) will moderate the experimental treatment effect, such that the benefit of dose titration will be greater in those participants who are rapid metabolizers of nicotine, and the final titrated dose they reach will be higher on average than the slow metabolizers

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Users become physically dependent on crack cocaine when they become tolerant to the drug, and start using higher amounts to achieve its effects

World Health Organization (WHO): Guidelines for Implementation of Article 11 of the WHO Framework Convention on Tobacco Control (Packaging and Labelling of Tobacco Products)

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