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The interrater agreement among the three reviewers, measured by Fleiss , was 86.1 percent, which is considered to be adequate

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Setting efficiency (deff) at 1.5, at 0.05 for a two-sided test with Z 1-/2 equal to 1.96, we calculated the sample size required for this study, which resulted in an estimated minimum sample size of 600 participants per country to be recruited as part of our research efforts