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Chronic and relapsing inflammation is at the core of inflammatory bowel disease (IBD), which is characterized by activation of the pro-inflammatory transcription factor nuclear factor-B (NF-B) [4] and increased expression of pro-inflammatory cytokines such as tumor necrosis (TNF)- in immune cells in the mucosa of IBD patients [5, 6]

This, again, is a mysterious requirement to us, which I frame abstractly as "Divine metaphysics" as I back away from the question

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