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Restak described it metaphorically as "the basis for the withdrawal response in addiction when the receptors, deprived of their usual supply of addicting substance, 'cry out' like deserted lovers for the missing chemical." Without the chemical for a long enough period of time, the receptors are "down regulated." The circuits of the brain adapt to the presence of nicotine, whose structure mimics the structure of a naturally occurring brain chemical called acetylcholine , a substance that releases another substance called dopamine

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He did say Pusha Ts name at least, however this was a weak ass response

Vaping relies on e-liquid to transmit nicotine

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