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Theres a range of effective forms of support for smoking cessation, and cytisine, varenicline, and e-cigarettes are all evidence-based ways to greatly increase peoples chances of successfully quitting smoking. Reference: Effects of interventions to combat tobacco addiction: Cochrane update of 2021 to 2023 reviews by Jonathan Livingstone-Banks, Nicola Lindson and Jamie Hartmann-Boyce, 04 September 2024, Addiction

Interestingly, cigarette smoke exposure depleted beneficial gut microbiota, including Bifidobacterium longum , and impaired SCFA production, particularly butyrate

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Tobacco control, 27(1), 10-17