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While the summary effect for the sales/purchases studies in the meta-analysis of cigarette elasticity with respect to ENDS price did not reach statistical significance, the prevalence/frequency/other outcomes studies (those not included in the meta-analysis) reported a consistent, albeit not always significant, increase in adult cigarette smoking in response to higher ENDS price, suggesting substitution

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Research from Washington State University found that CBD can inhibit nicotine metabolism by targeting key liver enzymes like CYP2A6

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