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Therefore, we aim to test a secondary hypothesis that baseline nicotine metabolite ratio (NMR) will moderate the experimental treatment effect, such that the benefit of dose titration will be greater in those participants who are rapid metabolizers of nicotine, and the final titrated dose they reach will be higher on average than the slow metabolizers

, smoking is the leading cause of preventable death in the United States

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If lung cancer is found, taking part in one of the many clinical trials being done to improve treatment should be considered