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According to the Global Adult Tobacco Survey (GATS), jointly conducted by the WHO and US Centers for Disease Control, 9% of Costa Ricas population smokes on a daily basis, meaning 300,000 Ticos can be considered regular smokers

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Further, given the complex association between exposure and outcome, creating a latent variable (such as a combination of different VOCs or HPHCs) might better capture and depict the mediation more accurately.

But this type of research can only show a link

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