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It has been a decades-long journey to go from food that was perceived as desperation to destination, Jeff Lenard, vice president of strategic industry initiatives for the National Association of Convenience Stores, said

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There are limited data on chronic effects, but a recent study evaluated the in vitro effects of the chronic exposure of endothelial cells to e-cigarette smoke, revealing a degree of endothelial dysfunction comparable to that induced by chronic exposure to traditional cigarette smoke [33]