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In particular, we would be interested in knowing if there is a single, common mechanism for all gateway drugs or if each drug utilizes a distinct mechanism. If nicotine works similarly in people, effective smoking cessation efforts might reduce the risk of addiction to cocaine and other illicit drugs.

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Detective Inspector Harris offers a Senior Service cigarette to Melville Farr in the film Victim (1961)

see Figure 3a) and when also controlling for all covariates (Model 3