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Nicotine and cotinine up-regulate vascular endothelial growth factor expression in endothelial cells
For decades, smoking received broad social legitimacy: It was presented as fashionable, social, calming, and even as a status symbol
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Has wear to the spine and a few creases to the covers
As nicotine is a ligand for nicotinic acetylcholine receptors (nAChRs) (Powledge 2004), it binds to nAChRs expressed in brain tissues with high affinity
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![Graphic News] Deaths caused by tobacco still climbing](https://wimg.heraldcorp.com/content/default/2017/04/23/20170423000300_0.jpg)
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