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Nicotine, the addictive constituent of tobacco, meets these criteria because a typical withdrawal syndrome occurs after smoking cessation, tolerance to its use develops, and most importantly, use persists after developing symptoms attributable to the substance and in the face of its known harm

Over time, this dryness can lead to an increased risk of tooth decay if you dont adopt proper preventive measures

[78] Reif JS, Bruns C, Lower KS

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Nicotine causes your arteries to become narrow