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3 Pharmacology and pathology of other SHS chemicals on the brain As discussed above, smoke from cigarettes or e-cigarettes contains many chemicals at levels comparable to nicotine ( see Table 1)

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Thus, when nicotine is no longer present, the pleasurable experience decreases and nicotine users feel the need for more nicotine in the body just to function normally, so they smoke another cigarette

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doi:10.1016/j.pbb.2004.06.005