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In the first wave of enrollment (20142017), electronic cigarette users reported their products as first, second and third generation devices (e-cig users) and were all largely current (i.e., dual) or former (sole) combustible cigarette users, whereas in the second wave of enrollment (20192020), electronic cigarette users all reported pod-based device use (pod users) and included more sole users who were never smokers

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It is not clear whether advanced aging is solely due to smoking cigarettes or exposure to cigarette smoke, or something found with many drugs of abuse