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Nicotine acts on the central and peripheral nervous system
Rickert WS, Joza PJ, Trivedi AH, Momin RA, Wagstaff WG, Lauterbach JH, et al
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performed a single-blind, randomized, crossover two-arm study to assess the effects of nicotine on the disposition kinetics of intravenously infused deuterium-labelled nicotine and cotinine and oral chlorzoxazone, verifying the hypotheses that nicotine reduces its own CYP2A6-mediated metabolism and induces CYP2E1 activity
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